Design, Synthesis, and Evaluation of DuocarmycinO-Amino Phenol Prodrugs Subject to Tunable Reductive Activation
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منابع مشابه
Synthesis and Biological Evaluation of Mutual Prodrugs of 2- {[3-(trifluoromethyl)phenyl]amino}benzoic Acid
For reducing the gastrointestinal (GI) toxicity associated with flufenamic acid (FA), its carboxylic group was masked by synthesizing its mutual prodrugs with propyphenazone by direct coupling and by using spacer technique. The structures of the synthesized mutual prodrugs (FE and FG) were confirmed by IR, H NMR, C NMR, mass spectroscopy and their purity were established by elemental analysis. ...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2010
ISSN: 0022-2623,1520-4804
DOI: 10.1021/jm1010397